David S Hains Selected Research

Ribonuclease 7

11/2021	Ribonuclease 7 polymorphism rs1263872 reduces antimicrobial activity and associates with pediatric urinary tract infections.
1/2016	Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract.
1/2015	Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.
5/2014	An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract.
4/2013	Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.
7/2011	Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.

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David S Hains Research Topics

Disease

14	Infections 01/2022 - 02/2009
8	Urinary Tract Infections (Urinary Tract Infection) 11/2021 - 05/2013
8	Pyelonephritis 01/2020 - 04/2013
5	Infertility (Sterility) 11/2015 - 07/2011
3	Cicatrix (Scar) 05/2017 - 10/2016
2	COVID-19 01/2021 - 01/2021
2	Pyuria 01/2020 - 02/2018
2	Urolithiasis 01/2015 - 05/2013
1	Brain Edema (Cerebral Edema) 01/2022
1	Congenital Heart Defects (Congenital Heart Defect) 01/2022
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 01/2022
1	Hyperammonemia 01/2022
1	Kidney Diseases (Kidney Disease) 01/2021
1	Chronic Renal Insufficiency 01/2021
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2020
1	Chronic Kidney Failure (Chronic Renal Failure) 10/2018
1	Fibrosis (Cirrhosis) 01/2017
1	Inflammation (Inflammations) 01/2017
1	Vesico-Ureteral Reflux (Vesicoureteral Reflux) 10/2016
1	Urologic Diseases (Urinary Tract Disease) 03/2016
1	Diabetes Mellitus 01/2016
1	Coinfection 05/2015
1	Acute Lung Injury 05/2015
1	Influenza in Birds (Avian Flu) 05/2015
1	Dental Caries (Decay, Dental) 04/2015
1	Brain Neoplasms (Brain Tumor) 04/2015
1	Kidney Calculi (Kidney Stone) 01/2015
1	Acidosis 10/2014
1	Osteopetrosis with renal tubular acidosis 10/2014
1	Pyelitis 05/2013
1	Cystitis 05/2013
1	Persistent Infection 05/2013
1	Disease Progression 05/2013
1	Nephrotic Syndrome (Syndrome, Nephrotic) 08/2012
1	Segmental glomerulosclerosis 01/2011

Drug/Important Bio-Agent (IBA)

10	Antimicrobial PeptidesIBA 11/2021 - 07/2011
6	Ribonuclease 7IBA 11/2021 - 07/2011
6	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2013
3	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 01/2015
3	Messenger RNA (mRNA)IBA 01/2015 - 01/2013
2	EnzymesIBA 01/2021 - 04/2013
2	leukocyte esteraseIBA 01/2020 - 02/2018
2	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2020 - 10/2014
2	Anti-Bacterial Agents (Antibiotics)IBA 02/2018 - 10/2016
2	Peptides (Polypeptides)IBA 05/2014 - 04/2013
1	AmmoniaIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	ImmunosorbentsIBA 01/2021
1	Immunoglobulin G (IgG)IBA 01/2021
1	Immunoglobulin M (IgM)IBA 01/2021
1	Protein CIBA 01/2020
1	cathepsin SIBA 01/2020
1	ChemokinesIBA 01/2020
1	transgelinIBA 01/2020
1	Mitogen-Activated Protein KinasesIBA 01/2020
1	Acetazolamide (Diamox)FDA LinkGeneric 01/2020
1	4-cresol sulfateIBA 10/2018
1	PolyaminesIBA 10/2018
1	Urea (Carbamide)FDA LinkGeneric 10/2018
1	IndicanIBA 10/2018
1	Uremic ToxinsIBA 10/2018
1	Succimer (Dimercaptosuccinic Acid)FDA Link 05/2017
1	Technetium Tc 99m Dimercaptosuccinic AcidIBA 05/2017
1	DefensinsIBA 10/2016
1	UroplakinsIBA 03/2016
1	Insulin (Novolin)FDA Link 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	Dietary Carbohydrates (Carbohydrate, Dietary)IBA 04/2015
1	Glycoproteins (Glycoprotein)IBA 04/2015
1	AgglutininsIBA 04/2015
1	Pancreatic Ribonuclease (Ribonuclease A)IBA 01/2015
1	Ribonucleases (Ribonuclease)IBA 01/2015
1	Calcium OxalateIBA 01/2015
1	Biological ProductsIBA 10/2014
1	Lipocalin-2IBA 10/2014
1	AcidsIBA 10/2014
1	StruviteIBA 05/2013
1	Adenosine Monophosphate (AMP)IBA 01/2012
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2011
1	TeratogensIBA 02/2009

Therapy/Procedure

1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2022
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2022
1	Renal Dialysis (Hemodialysis) 01/2021
1	Kidney Transplantation 01/2020
1	Immunomodulation 01/2017
1	Therapeutics 01/2017
1	Antibiotic Prophylaxis 10/2016
1	Cystostomy (Suprapubic Cystostomy) 05/2013
1	Urinary Diversion (Ileal Conduit) 05/2013
1	Length of Stay 08/2012